The effects of Cu on the growth rate and amino acids profile of Chlorella sp. were determined in 72 hrs exposure experiments at Cu concentrations over the range 1 – 10 µg/L. The Cu concentration required to inhibit algal growth rate by 10 % (EC10) and 50 % (EC50) was found to be 1.0 ± 0.1 µg/L and 2.0 ± 0.1 µg/L respectively. Copper stress caused a significant change in the amino acid profile of Chlorella sp. compared to the controls with an increase in amino acids like Lysine, Alanine and Glycine.